ben-u-ron

for pain and fever

• Mild to moderate pain
• Fever
• In 1959, bene-Arzneimittel launched ben-u-ron^® as the first paracetamol preparation on the German market, and the medicinal product has since been used to treat non-inflammatory pain and fever in patients of all ages.
   
• For instance, it is particularly suitable for treating headaches, menstrual pain and toothaches.
• The active ingredient of ben-u-ron^®, paracetamol, is still the only one which can be taken throughout pregnancy if necessary.

• Unique variety of products – unique tolerability
• Unique 75 mg suppositories without additives, free of emulsifiers
• Unique paracetamol syrup without organic solvents, with dosing syringe
• Unique 500 mg capsules
• Unique PCM direct granulate with improved flavour, easy to swallow

The ben-u-ron^® preparations listed below are available only from pharmacies. In case of questions on risks and side effects, please contact your doctor or pharmacist. All details on the exact application, dosage and ingredients are found on the linked package leaflet. You can find a dosage table for all available forms here. These are in German. If you need detailed English information, please contact us.

Paracetamol is a so-called nonacidic antipyretic.
Its mode of action is multifaceted but centres on the central nervous system and spinal cord.
In detail, the following individual effects of paracetamol combine in such a way that the total effect is greater than the sum of its individual components (hyperadditive, synergistic effect). 

1. Inhibits the enzymes involved in pain development (cyclooxygenases), the pain-generating substances produced by them (prostaglandins) and messengers and mediators (nitrogen monoxide, substance P) in the central nervous system.
    
2. ​Enhances the body’s pain-inhibiting systems
   • Activates serotoninergic pain inhibition pathways
   • Interacts with the cannabinoid pain inhibition system
   • Affects opioid receptors

Paracetamol reduces fever by centrally acting on the centre responsible for regulating body temperature in the hypothalamus.