Bladder Pain Syndrome

Interstitial Cystitis (IC) is a severe and debilitating condition of the bladder, characterized by the symptoms of pelvic pain, urinary urgency and frequency, nocturia, and frequently dyspareunia. A commonly agreed cause for IC is a defect or alteration in the bladder surface leading to increased permeability to noxious urinary solutes and ultimately to tissue inflammation and neurogenic upregulation. Lately the more general umbrella term bladder pain syndrome followed by the indication (BPS/IC), was introduced.


The etiology of IC has yet to be conclusively settled. An increased number of activated mast cells are often seen in the bladder wall of IC patients. Upon activation mast cells release several kinds of inflammatory mediators. Recent research has implicated changes in the levels of growth factors and compounds that protect against irritants and potentially "toxic" factors.

Reported prevalences for IC in Europe are documenting the relevance for health economic. Internationally numbers on prevalence are depending on author, country and definition in between 10 and 900 / 100.000. Affected population are mostly women at the age of 40 years and older.


Our recommendation

Cyst-u-ron is a medical product, approved by the competent health authorities for a repeated, temporary intravesical application to replace a defective epithelial layer (GAG) of the bladder.

cyst-u-ron helps to enhance quality of life by relieving symptoms among patients with an Interstitial Cystitis and other symptoms associated with a Bladder Pain Syndrome.